The incident took place in the town of Gilib, 350 kilometers south of Mogadishu, a Press TV correspondent reported on Sunday.
Meanwhile, other US drones also crashed near the Balet Weyne Town in Hiiraan. Further details have not been released yet.
Southern Somalia is also a stronghold of al-Shabab fighters.
Somalia is the sixth country where the US military has conducted drone strikes.
The US has deployed bombing and intelligence drones in Afghanistan, Pakistan, Libya, Iraq and Yemen to launch aerial missile attacks.
Washington claims the airstrikes target militants, though most such attacks have resulted in civilian casualties.
Somalia has been without a functioning government since 1991, when warlords overthrew former dictator Mohamed Siad Barre.
US drone kills 28 in south Somalia
Another attack by a US assassination drone has claimed the lives of at least 28 civilians, while injuring dozens of others in southern Somalia, Press TV reports.
